Generic Name : Naproxen
Brand name: Naprosyn
Naprosyn Drug Uses
One of the main functions of the kidneys is to retain salt (sodium chloride) and water. In patients with heart failure and cirrhosis, increased levels of a hormone produced by the adrenal glands, called aldosterone, causes salt and fluid retention by the kidneys. Spironolactone inhibits the action of aldosterone causing the kidneys to excrete salt and fluid while retaining potassium. Therefore, spironolactone is classified as a potassium-sparing medication that promotes the output of urine (diuretic).
How Naprosyn Drug Works
Take Naprosyn with food or immediately after a meal to prevent stomach upset. Try to take Naprosyn at the same time each day. This may help you to remember to take it. Learn proper use of your particular brand of medication. Follow your dosing schedule carefully. Be sure to ask your doctor or pharmacist if you have any questions. Use a supplemental form of birth control during the first week of taking Naprosyn since it takes a while to be effective. Follow your doctor's directions exactly if this drug is being used as a "morning after" pill.
How Naprosyn Taken
A measuring cup marked in 1/2 teaspoon and 2.5 milliliter increments is provided with the suspension. This cup or a teaspoon may be used to measure the appropriate dose.
Possible Naprosyn Side Effects
Possible Causal Relationship: Adverse reactions reported in controlled clinical trials in 960 patients treated for rheumatoid arthritis or osteoarthritis are listed below. In general, these reactions were reported 2 to 10 times more frequently than they were in studies in the 962 patients treated for mild to moderate pain or for dysmenorrhea.
A clinical study found gastrointestinal reactions to more frequent and more severe in rheumatoid arthritis patients taking 1500 mg naproxen daily compared to those taking 750 mg daily. (See CLINICAL PHARMACOLOGY.)
In controlled clinical trials with about 80 children and in well-monitored open studies with about 400 children with juvenile arthritis, the incidences of rash and prolonged bleeding times were increased, the incidences of gastrointestinal and central nervous system reactions were about the same, and the incidences of other reactions were lower in children than in adults.
Naprosyn Warnings/Precautions
Risk of GI Ulceration, Bleeding and Perforation with NSAID Therapy
Serious gastrointestinal toxicity such as bleeding, ulceration, and perforation, can occur at any time, with or without warning symptoms, in patients treated chronically with NSAID therapy. Although minor upper gastrointestinal problems, such as dyspepsia, are common, usually developing early in therapy, physicians should remain alert for ulceration and bleeding in patients treated chronically with NSAIDs even in the absence of previous GI tract symptoms. In patients observed in clinical trials of several months to two years duration, symptomatic upper GI ulcers, gross bleeding or perforation appear to occur in approximately 1% of patients treated for 3-6 months, and in about 2-4% of patients treated for one year. Physicians should inform patients about the signs and/or symptoms of serious GI toxicity and what steps to take if they occur.
Naprosyn Overdose
Significant overdosage may be characterized by drowsiness, heartburn, indigestion, nausea or vomiting. A few patients have experienced seizures, but it is not clear whether or not these were drug related. It is not known what dose of the drug would be life threatening. The oral LD50 of the drug is 543 mg/kg in rats, 1,234 mg/kg in mice, 4,110 mg/kg in hamsters and greater than 1,000 mg/kg in dogs.Should a patient ingest a large number of tablets or a large volume of suspension, accidentally or purposefully, the stomach may be emptied and usual supportive measures employed. In animals 0.5 g/kg of activated charcoal was effective in reducing plasma levels of naproxen. Hemodialysis does not decrease the plasma concentration of naproxen because of the high degree of its protein binding.
Naprosyn Drug Interactions
The drug is contraindicated in patients who have had allergic reactions to naproxen. It is also contraindicated in patients in whom aspirin or other nonsteroidal anti-inflammatory/analgesic drugs induce the syndrome of asthma, rhinitis, and nasal polyps. Both types of reactions have the potential of being fatal. Anaphylactoid reactions to naproxen whether of the true allergic type ot the pharmacologic idiosyncratic (e.g., aspirin syndrome) type, usually but not always occur in patients with a known history of such reactions. Therefore, careful questioning of patients for such things as asthma, nasal polyps, urticaria, and hypotension associated with nonsteroidal anti-inflammatory drugs before starting therapy is important. In addition, if such symptoms occur during therapy, treatment should be discontinued.
Naprosyn Missed Dose
Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Naprosyn Storage
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
Naprosyn More Information
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
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